Is aldactone dangerous if I were to become pregnant while on it.?

by Admin on October 12, 2009

My husband and I use condoms, we are not trying to have a baby. I just want to make sure we are aware of any risks we are taking due to that being the only form of birth control we use.

{ 1 comment… read it below or add one }

heather j October 12, 2009 at 7:13 pm

Read the following .. I took this from the site and this is the part about Pregnancy.

Pregnancy

Teratogenic Effects: Pregnancy Category C.Teratology studies with spironolactone have been carried out in mice and rabbits at doses of up to 20 mg/kg/day. On a body surface area basis, this dose in the mouse is substantially below the maximum recommended human dose and, in the rabbit, approximates the maximum recommended human dose. No teratogenic or other embryotoxic effects were observed in mice, but the 20 mg/kg dose caused an increased rate of resorption and a lower number of live fetuses in rabbits. Because of its anti-androgenic activity and the requirement of testosterone for male morphogenesis, Aldactone may have the potential for adversely affecting sex differentiation of the male during embryogenesis. When administered to rats at 200 mg/kg/day between gestation days 13 and 21 (late embryogenesis and fetal development), feminization of male fetuses was observed. Offspring exposed during late pregnancy to 50 and 100 mg/kg/day doses of spironolactone exhibited changes in the reproductive tract including dose-dependent decreases in weights of the ventral prostate and seminal vesicle in males, ovaries and uteri that were enlarged in females, and other indications of endocrine dysfunction, that persisted into adulthood. There are no adequate and well-controlled studies with Aldactone in pregnant women. Spironolactone has known endocrine effects in animals including progestational and antiandrogenic effects. The antiandrogenic effects can result in apparent estrogenic side effects in humans, such as gynecomastia. Therefore, the use of Aldactone in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the fetus.

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